Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 387-393, 2019.
Article
in En
| WPRIM
| ID: wpr-776872
Responsible library:
WPRO
ABSTRACT
Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher's reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.
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WPRIM
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article