Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 582-588, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-777461
ABSTRACT
To evaluate the efficacy and safety of huperzine in treating patients with mild cognitive impairment. The randomized controlled trials(RCT) were retrieved from EMbase, Cochrane Library, PubMed, CNKI, Wanfang and VIP. The methodology quality of the included studies was evaluated, and a Meta-analysis was performed using RevMan 5.3 software. A total of nine RCTs were included. The Meta-analysis results showed that compared with placebo, Huperzine significantly increased the scores of memory quotient(MQ) and mini-mental state examination(MMSE). However, there was no statistical difference between oral tablet and capsule. Compared with placebo, huperzine A was superior in the scores of MQ and MMSE. Huperzine is safe with mild side effects. Due to the low quality of original studies, more high-quality studies are needed to verify its efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Randomized Controlled Trials as Topic
/
Therapeutic Uses
/
Drug Therapy
/
Alkaloids
/
Cognitive Dysfunction
/
Memory
Type of study:
Controlled clinical trial
/
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article
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