Prognostic values of preoperative serum CA199 and NSE on esophageal squamous cell carcinoma patients / 中华疾病控制杂志
Chinese Journal of Disease Control & Prevention
; (12): 134-139, 2019.
Article
in Zh
| WPRIM
| ID: wpr-777933
Responsible library:
WPRO
ABSTRACT
Objective To explore the effects of preoperative serum cancer antigen 19-9 (CA19-9) and neuron-specific enolase (NSE) on the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods This prospective study enrolled 176 patients with ESCC. 2 test was used to analyze the relationship between CA19-9, NSE and general clinical features. Survival curves were estimated using Kaplan-Meier method and comparisons were performed using the log-rank test. The Cox proportional hazards model was performed for multivariate analyses of overall survival (OS) and disease free survival (DFS). Results The patients with both high CA19-9 and NSE had the poor prognosis compared with those had both low CA19-9 and NSE (OS HR=2.310, 95% CI 1.208-4.418; DFSHR=2.354, 95% CI:1.265-4.381). Compared to the separate detection of the two markers, the combined detection of CA19-9 and NSE was more accurate in the prognosis prediction of patients with ESCC (OSC-index=0.686; DFSC-index=0.684). Conclusions Preoperative serum CA19-9 and NSE were risk factors for the prognosis of patients with ESCC. Combined detection had higher accuracy of prediction of prognosis in patients with ESCC.
Full text:
1
Index:
WPRIM
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Disease Control & Prevention
Year:
2019
Type:
Article