Research progress in medicines on protease-activated receptor 2 / 药学学报
Acta Pharmaceutica Sinica
; (12): 362-2016.
Article
in Zh
| WPRIM
| ID: wpr-779177
Responsible library:
WPRO
ABSTRACT
Protease-activated receptor 2 (PAR2) is a member of protease-activated receptors (PARs). PAR2 distributed in tissues and cells (such as skin, airway epithelial cell, pancreas, etc.) has a broad biological effects, and is involved in pathogenesis of many diseases, such as mechanical pain, asthma, pain of pancreatic cancer, inflammation, pruritus, etc. Intervention of PAR2 will help us to identify the role of PAR2 in the mechanisms of diseases and in the development of new drugs. This article concentrates on the research progress of agonist, antagonist, and pepducin on PAR2.
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WPRIM
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article