High Prevalence of Thyroid Disease and Role of Salivary Gland Scintigraphy in Patients with Xerostomia / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
; : 169-177, 2017.
Article
in En
| WPRIM
| ID: wpr-786917
Responsible library:
WPRO
ABSTRACT
PURPOSE: Although Sjögren's syndrome (SS) is the most common disease causing xerostomia, autoimmune thyroid diseases can also affect the salivary glands. The aim of our study was to estimate the prevalence of thyroid diseases (TD) in subjects with symptoms of xerostomia and evaluate the efficacy of salivary gland scintigraphy (SGS) in the detection of TD in patients with SS and without SS.METHODS: We retrospectively reviewed the SGS findings of 173 subjects (men:women, 29:144) with symptoms of xerostomia. Ejection fractions (EF) in the parotid and submandibular glands were calculated. Thyroid disease was diagnosed on the basis of the results of the visual assessment of tracer uptake in the thyroid gland on SGS images as well as serological thyroid function tests.RESULTS: Based on the American-European Criteria, 94 patients were diagnosed with SS. Hashimoto's thyroiditis was diagnosed in 63 patients, subacute thyroiditis in 23, subclinical hypothyroidism in five, and Graves' disease in one. There were significant differences in the EF values of the parotid and submandibular glands between patients with TD and those with undetermined diagnoses.CONCLUSIONS: More than half of patients with xerostomia exhibited TD. Thyroid assessment by SGS is feasible, and SGS appears to be useful for the patients with xerostomia caused by TD. SGS may be the first imaging modality capable of evaluating both salivary gland function and thyroid gland status in patients with xerostomia. This strategy would make the requirement for additional workup for thyroid disease.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Salivary Glands
/
Submandibular Gland
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Thyroid Diseases
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Thyroid Function Tests
/
Thyroid Gland
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Thyroiditis
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Xerostomia
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Thyroiditis, Subacute
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Radionuclide Imaging
/
Graves Disease
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
Limits:
Humans
Language:
En
Journal:
Korean Journal of Nuclear Medicine
Year:
2017
Type:
Article