The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment / 생물치료정신의학
Journal of the Korean Society of Biological Therapies in Psychiatry
; (3): 28-35, 2019.
Article
in Ko
| WPRIM
| ID: wpr-787401
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.METHODS:
We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulin-like growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIA-AA) working group.RESULTS:
When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.CONCLUSION:
The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Aging
/
Insulin-Like Growth Factor I
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Dementia
/
Diagnosis
/
Cognitive Dysfunction
/
Necrosis
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Aged
/
Humans
Language:
Ko
Journal:
Journal of the Korean Society of Biological Therapies in Psychiatry
Year:
2019
Type:
Article