Acute obstructive fi brinous laryngotracheobronchitis induced by severe glyphosate surfactant intoxication: A case report / 世界急诊医学杂志（英文）

ABSTRACT

@#Glyphosate is a nonselective herbicide commonly used in agriculture worldwide. Glyphosate targets the shikimate metabolic pathway, which is found in plants but not in animals. Therefore, it is considered to be of low toxicity to humans, supported by the finding of high concentrations of oral and dermal LD50 (>5,000 mg/kg body weight) of glyphosate in experimental animals.[1,2] Ingesting commercial formulations of glyphosate surfactant herbicide (GlySH), however, has been reported to be associated with various toxic effects, including gastrointestinal injury, laryngeal injury, impaired renal function, metabolic acidosis, arrhythmias, pulmonary toxicity, shock, and even death.[3] Recently, glyphosate surfactant has been used with increasing frequency in suicide attempts, and clinical toxicologists have encountered fatal cases of glyphosate surfactant poisoning.[4] Mortality from ingesting glyphosate surfactant varies from 0% to 29.3%, depending on patients’ characteristics such as age and intent of exposure. [5–7] Acute fi brinous laryngotracheobronchitis is often seen in infants and children, but it is rare in adults. Here we present a case with acute obstructive fibrinous laryngotracheobronchitis induced by severe glyphosatesurfactant intoxication.