Oncologic outcomes of squamous cell carcinoma of the anal canal after chemoradiation therapy
Korean Journal of Clinical Oncology
; (2): 41-47, 2016.
Article
in En
| WPRIM
| ID: wpr-787976
Responsible library:
WPRO
ABSTRACT
PURPOSE: The aim of this study is to analyze the oncological outcomes of squamous cell carcinoma (SCC) of the anal canal after chemoradiation therapy (CRT) in a single institution.METHODS: Fifty-one patients with anal SCC who had been treated with CRT between January 2000 and December 2010 were analyze data single center in Korea.RESULTS: Forty-eight patients exhibited clinical complete response. After a median follow-up of 42.1 months, 13 patients (25.5%) showed recurrence. The disease-free survival (DFS) rate was 63.4% at 5 and 10 years. The overall survival (OS) rates were 83.6% (5 years) and 75.2% (10 years). Stage I: DFS, 100%; OS, 100%; stage II: DFS, 85.7%; OS, 100%; stage IIIA: DFS, 68.6%; OS, 87.5%; stage IIIB: DFS, 34.7%; OS, 48.4%; and stage IV: DFS and OS, 0%. The local recurrence patterns were as follows: pelvic node (n=4, 7.8%), inguinal node (n=1, 2.0%), and inguinal and pelvic node (n=1, 2.0%). The systemic recurrence patterns were as follows: lung (n=2, 3.9%), para-aortic node (n=1, 2.0%), and extrapelvic site (n=2, 3.9%). N-stage represented a single independent prognostic factor for recurrence (P<0.05).CONCLUSION: CRT for SCC of the anal canal is effective for oncological outcomes and sphincter preservation. The initial nodal status may affect the oncological outcome.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Anal Canal
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Anus Neoplasms
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Recurrence
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Carcinoma, Squamous Cell
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Follow-Up Studies
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Disease-Free Survival
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Epithelial Cells
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Chemoradiotherapy
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Korea
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Lung
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Korean Journal of Clinical Oncology
Year:
2016
Type:
Article