New insights of the pathogenesis and prognostic factors of Epstein-Barr virus-associated extranodal NK/T-cell lymphoma / 中国医师杂志
Journal of Chinese Physician
; (12): 1595-1599, 2019.
Article
in Zh
| WPRIM
| ID: wpr-797094
Responsible library:
WPRO
ABSTRACT
Extranodal NK/T-cell lymphoma (ENKTL) is a rare, invasive extra nodal non-Hodgkin's lymphoma (NHL) that is commonly associated with Epstein-Barr virus (EBV). ENKTL is the commonest to men with no apparent immunodeficiency in Asia and South America. Except for EBV, no environmental or external factors are associated with tumorigenesis. The precise mechanism by which EBV infects NK or T cells and the role of the virus in the pathogenesis of ENKTL has not been fully deciphered. However, many recent discoveries have been identified, including disorders of cell signaling and mutations in tumor suppressor genes, which provide insight into the pathogenesis of ENKTL. Moreover, NK/T cell non-Hodgkin's lymphoma generally has a poor prognosis, and research on its prognostic factors is still ongoing. This article focuses on the pathogenesis and prognostic factors of ENKTL, and attempts to provide direction for improving patient outcomes.
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
/
Prognostic_studies
Language:
Zh
Journal:
Journal of Chinese Physician
Year:
2019
Type:
Article