Advances in inflammasome and pulmonary disease and its intervention / 中华实用儿科临床杂志

ABSTRACT

Nucleotide-binding oligomerization domain like receptors (NLRs) can recognize conserved sequences of microorganisms and initiate inflammation, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is one of the most representative members of the NLRs family.Activated by a variety of endogenous or exogenous dangerous signals, NLRP3 combines with apoptosis-associated speck-like protein(ASC) and caspase-1 to form inflammasome.And then it acts on downstream inflammatory factors such as inter-leukin-1β (IL-1β) and interleukin-18 (IL-18) to promote their maturation and secretion.At the same time, it can interact with gasdermin D(GSDMD)and eventually lead to pyroptosis.It was found that, NLRP3 was closely related to the occurrence and development of pulmonary diseases.Finding inhibitors of key proteins in NLRP3 inflammasome pathway may provide a new way to treat related diseases.This article reviews the composition of NLRP3 inflammasome, the relationship between NLRP3 inflammasome and the occurrence of pulmonary diseases, and the advances in intervention research.