Clinical analysis of endovascular repair with covered stent in the treatment of 40 patients with Stanford B type aortic dissection / 中国基层医药

ABSTRACT

Objective@#To evaluate the efficacy and safety of endovascular repair with covered stent in the treatment of Stanford B-type aortic dissection.@*Methods@#The clinical data of 40 patients with Stanford B-type aortic dissection who underwent endovascular repair with covered stent in the People's Hospital of Suqian, Nanjing Drum-Tower Hospital Group from January 2012 to December 2017 were retrospectively analyzed.The incidence of complications before and after treatment, and its influence on the serum levels of IL-1β, INF-γ, VEGF were analyzed.After one year follow-up, the changes of quality of life score before and after surgery, and the mortality, reoperation or interventional treatment within one year after operation were compared.@*Results@#Forty patients were successfully implanted with stent grafts, 5 cases of which had a small amount of endoleak, 1 case had postoperative cerebral infarction, and no complications such as paraplegia or renal failure were observed.Compared with before treatment, the serum levels of IL-1β, INF-γ and VEGF were significantly down-regulated after treatment[(3.24±0.19)ng/L vs.(2.02±1.16)ng/L, (2.65±0.23)ng/L vs.(1.14±1.27)ng/L, (1.51±0.17)ng/mL vs.(0.73±0.34)ng/mL], the differences were statistically significant(t=5.037, P=0.001; t=6.071, P=0.000; t=7.314, P=0.000). After 1 year of follow-up, the mortality rate was 5.00%(2/40), and the rate of reoperation or intervention was 5.00%(2/40). The postoperative quality of life(QLQC-30) of the patients was scored in different dimensions emotional function, body function, role function, cognitive function and social function after 1 month, 6 months and 12 months, the differences were statistically significant(F=6.134, 7.109, 5.134, 6.925, 5.197, all P=0.000).@*Conclusion@#Endovascular repair with covered stent in the treatment of Stanford B aortic dissection can significantly improve the clinical symptoms of patients, with significant effects and less complications, and can significantly improve patients' survival and quality of life.