The effect of aerobic endurance exercise on renal fibrosis and the expression of TGF-beta 1 and E-cadherin in aged mice / 中华物理医学与康复杂志
Chinese Journal of Physical Medicine and Rehabilitation
;
(12): 801-806, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-801197
ABSTRACT
Objective@#To explore the effect of aerobic endurance exercise on renal fibrosis in elderly mice and its possible mechanism.@*Methods@#Thirty-six healthy, male C57 mice were sorted into a young control group (2 months old), a senile control group (19 months old) and a senile exercise group (also 19 months old). The senile exercise group underwent aerobic endurance exercise for 7 weeks. Then all of the mice were sacrificed and any changes of in their renal tissues were recorded, especially the expression of fibrosis indicators using HE staining, Sirius red staining, RT-PCRs and immunohistochemical methods.@*Results@#Collagen fibers deposited in the kidney tissue of the senile groups were significantly more numerous than in the young control group, but their number had decreased significantly after the exercise.@*Conclusion@#Aerobic endurance exercise can inhibit collagen deposition and delay the formation of renal fibrosis, at least in rats. This may be related to its inhibition of TGF-β1 and α-SMA expression and up-regulation of E-cadherin expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Physical Medicine and Rehabilitation
Year:
2019
Type:
Article
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