Research Progress on Amelioration of Hemorrhagic Stroke by Traditional Chinese Medicine / 中国实验方剂学杂志

ABSTRACT

Cerebral hemorrhage, also known as hemorrhagic stroke, refers to non-traumatic intracerebral hemorrhage. Cerebral hemorrhage is a common and frequently-occurring disease in middle-aged and elderly people. It has the characteristics of high mortality and high disability rate. Most survivors have serious neurological deficits, which seriously threaten human health and quality of life.The pathological process of cerebral hemorrhage is more complicated, including the formation and expansion of hematoma, elevated intracranial pressure, destruction of blood-brain barrier, brain edema, neuronal apoptosis and neurological dysfunction.At present, the main methods for treating cerebral hemorrhage by western medicine include antiplatelet therapy, blood pressure reduction and hematoma surgery. However, it is usually accompanied by the risk of rebleeding caused by surgery, infection, nerve damage and insufficient effective perfusion pressure. Chinese medicine believes that blood stasis and endogenous fever are the most basic pathogenesis of acute cerebral hemorrhage. The previous studies found that many traditional Chinese medicine(TCM) can improve blood-brain barrier damage, brain edema, neuronal apoptosis and neurological dysfunction related to cerebral hemorrhage to reduce cerebral hemorrhage injury. Main signal transduction pathways regulated by TCM to treat cerebral hemorrhageinclude Aquaporin 4(AQP4)-related, phosphatidylinositol-3-kinase/protein kinase B(PI3K/Akt), nuclear factor kappa B(NF-κB),suppressor protein 53/Bcl-2-associated X protein/Caspase-3(p53/Bax/Caspase-3)molecular pathways, etc.In this paper, based on the current Chinese medicine to improve the brain damage caused by cerebral hemorrhage and the molecular pathway of intervention, it reviews the research progress published in foreign journals in the past ten years, in order to provide clues and reference for the treatment of hemorrhagic stroke diseases and and the further development of new drugs.