Preoperative molecular testing on fine-needle aspiration in precision management of thyroid cancer / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
; (12): 58-61, 2019.
Article
in Zh
| WPRIM
| ID: wpr-804675
Responsible library:
WPRO
ABSTRACT
This article focuses on the controversial issues in the diagnosis and treatment of thyroid cancer. Several commonly used molecular tests, especially gene mutation and fusion detection, in the preoperative diagnosis of thyroid nodules and the prognosis evaluation of thyroid cancer are introduced. For the thyroid nodules with uncertain indeterminate cytology, different molecular screening methods have their own advantages and disadvantages. Among them, DNA detection, especially multi-gene molecular testing based on next-generation sequencing has better sensitivity and specificity. Besides being used in diagnosis, it can also detect gene mutations related to tumor prognosis, such as BRAFV600E mutation and TERT promoter mutation, which is increasingly widespread and accepted.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2019
Type:
Article