Study on virulence related sites based on human enterovirus A71 genome / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 318-322, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-806195
ABSTRACT
Objective@#To explore the virulence related risk factors based on the enterovirus A71 (EV-A71) genome.@*Methods@#The pairwise distance of each section of gene between mild and fatal cases was analyzed. The ⅴ domain of 5′UTR from mild and fatal cases in this study were constructed. Amino acid sequences of EV-A71 were analyzed to find the potential virulence regions which were statistically different between fatal and mild cases.@*Results@#The two EV-A71 genome sequences in this study belonged to C4a genotype with the genomic homology of 96.2%-97.5%. The nucleotides in the ⅴ domains of the 5 ′UTR of EV-A71 from mild and fatal cases were the same. Each gene of EV-A71 from 31 mild cases and 30 fatal cases shared high homology. A total of four potential virulence sites (2 A R68 M、2C K41R、3 A T/V47 A and 3C I158 V) which were significantly different between mild cases and fatal cases were obtained.@*Conclusions@#The four sites in the unstructured protein coding region might be related with the virulence of EV-A71.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2018
Type:
Article
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