Research progress in antiviral effects of SERINC family proteins / 中华实验和临床病毒学杂志

ABSTRACT

Serine incorporator (SERINC) is a multi-transmembrane family of carrier proteins that is highly conserved among species and helps to integrate serine into lipid bilayers to efficiently synthesize phospholipids Phosphatidylserine and sphingolipids. Recent studies have found that SERINC protein family, especially SERINC3 and SERINC5, act on many different viruses, such as human immunodeficiency virus (HIV) which causes AIDS, inhibit the replication and proliferation of the virus to achieve antiviral effects. The study on the mechanism of virus-host cell interaction has been a hot spot in the field and has important scientific significance. In this article, the structural features of SERINC protein family, the major biological functions, and the interaction with the virus in the anti-virus process are summarized in order to provide important information for the research on the host-virus interaction.