Relationship between hepatitis C virus and serine protease inhibitor Kazal1 / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 599-601, 2018.
Article
in Zh
| WPRIM
| ID: wpr-806646
Responsible library:
WPRO
ABSTRACT
Objective@#To explore the effect of hepatitis C virus (HCV) on the expression of serine protease inhibitor Kazal1 (SPINK1) and its clinical implication.@*Methods@#mRNA and protein expression of SPINK1 in Huh7.5.1 cells infected by HCV JFH-1 and the control cells were measured by RT-PCR and western blotting, SPINK1 levels in the cell supernatants and sera of HCV patients were measured by enzyme-linked immunosorbent assay (ELISA), the difference of SPINK1 levels between healthy controls and HCV patients was analyzed.@*Results@#Expression of SPINK1 mRNA and protein was higher in Huh7.5.1 cells infected by HCV JFH-1 than in the control cells, serum SPINK1 levels was much higher in HCV patients than in healthy controls (P=0.016).@*Conclusions@#HCV can upregulate the expression of SPINK1.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2018
Type:
Article