Aspiration Cytology of the Osteoclastic Variant of Anaplastic Thyroid Carcinoma: with Special Emphasis on the Undifferentiated Mononuclear Cells
Korean Journal of Pathology
; : 682-686, 2010.
Article
in En
| WPRIM
| ID: wpr-80785
Responsible library:
WPRO
ABSTRACT
Anaplastic thyroid carcinoma (ATC) is an uncommon aggressive malignant tumor, and the osteoclastic variant of ATC is extremely rare. We report here on the fine needle aspiration cytology of the osteoclastic variant of ATC in an 83-year-old woman. The smear was composed of many oval to slightly elongated undifferentiated mononuclear cells admixed with multinucleated osteoclast-like giant cells. The mononuclear tumor cells revealed inconspicuous nuclear pleomorphism and the nuclei were characterized by vesicular chromatin and an indented or lobulated nuclear membrane with conspicuous nuclear grooves. A few epithelial clusters suggestive of a papillary carcinoma component were also observed. Making the proper cytological diagnosis of the osteoclastic variant of ATC is helpful to determine the proper treatment modality for these patients.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Osteoclasts
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Thyroid Gland
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Thyroid Neoplasms
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Chromatin
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Carcinoma, Papillary
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Giant Cells
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Biopsy, Fine-Needle
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Anaplasia
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Nuclear Envelope
Limits:
Aged
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Aged80
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Female
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Humans
Language:
En
Journal:
Korean Journal of Pathology
Year:
2010
Type:
Article