Association of single nucleotide polymorphism of IL-6 gene with susceptibility to hepatitis B virus / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 397-400, 2017.
Article
in Zh
| WPRIM
| ID: wpr-808646
Responsible library:
WPRO
ABSTRACT
Objective@#Leukocyte mediated IL-6 (IL-6) plays an important role in chronic viral hepatitis pathogenesis and related liver diseases, We did a large sample-size case-control study and clinical data analysis to find association between IL-6 single nucleotide polymorphism and HBV susceptibility, and to achieve the detection of the body on the expression of IL-6 for the prevention and treatment of HBV infection.@*Methods@#Totally 848 HBV patients and 894 healthy controls in Shenzhen were selected and rs1800796 genotypes were determined by TaqMan assays.@*Results@#The result showed that rs1800796 polymorphism was associated with susceptibility to HBV infection (P=0.0003, odds ratio (OR)=1.43, the difference was statistically significant.@*Conclusions@#The single nucleotide polymorphism of IL-6rs1800796 locus was associated with the susceptibility of HBV infection in Chinese population, and the rs1800796 G allele is a protective gene for HBV infection.
Full text:
1
Index:
WPRIM
Type of study:
Observational_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2017
Type:
Article