A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation
Obstetrics & Gynecology Science
;
: 328-332, 2016.
Article
in English
| WPRIM
| ID: wpr-81072
ABSTRACT
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of embryology. Here, we describe the case of a 52-year-old woman with malignant FATWO. The patient underwent explorative laparotomy and surgical staging after a frozen section revealed malignancy. Detailed examination of the pathologic findings were consistent with FATWO. Counseling and further testing were provided to the patient to assess the risk of germline mutation and epigenetic change. An O-6-methylguanine-DNA methyltransferase gene methylation test was positive, and all other tests were normal. This is the first study to report a case of O-6-methylguanine-DNA methyltransferase methylation with FATWO in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Wolffian Ducts
/
Embryology
/
Germ-Line Mutation
/
Counseling
/
Rare Diseases
/
Epigenesis, Genetic
/
Epigenomics
/
Frozen Sections
/
Korea
/
Laparotomy
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2016
Type:
Article
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