Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
; : 2-2020.
Article
in En
| WPRIM
| ID: wpr-811180
Responsible library:
WPRO
ABSTRACT
Acute viral infection or vaccination generates highly functional memory CD8 T cells following the Ag resolution. In contrast, persistent antigenic stimulation in chronic viral infection and cancer leads to a state of T-cell dysfunction termed T-cell exhaustion. We and other have recently identified a novel subset of exhausted CD8 T cells that act as stem cells for maintaining virus-specific CD8 T cells in a mouse model of chronic lymphocytic choriomeningitis virus infection. This stem cell-like CD8 T-cell subset has been also observed in both mouse and human tumor models. Most importantly, in both chronic viral infection and tumor models, the proliferative burst of Ag-specific CD8 T cells driven by PD-1-directed immunotherapy comes exclusively from this stem cell-like CD8 T-cell subset. Therefore, a better understanding of the mechanisms how CD8 T-cell subsets are regulated during chronic viral infection and cancer is required to improve the current immunotherapies that restore the function of exhausted CD8 T cells. In this review, we discuss the differentiation of virus-specific CD8 T cells during chronic viral infection, the characteristics and function of CD8 T-cell subsets, and the therapeutic intervention of PD-1-directed immunotherapy in cancer.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Stem Cells
/
T-Lymphocytes
/
T-Lymphocyte Subsets
/
Vaccination
/
Immunotherapy
/
Lymphocytic choriomeningitis virus
/
Memory
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Immune Network
Year:
2020
Type:
Article