Preparation of pumiloside and identification of its metabolites in rats by UPLC-QTOF/MS / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 677-682, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-811990
ABSTRACT
@#In this paper, water extract of Nauclea officinalis was absorbed by AB-8 macroporous resin and subsequently gradient-eluted with alcoholic solution of different proportion to prepare pumiloside monomer of high purity. The metabolites in urine, feces and bile of rats with gavage administration were analyzed by UPLC-QTOF/MS. Accurate MS/MS data of all components were collected with full scan mode, and analyzed by MetaboLynx software. Results showed that the monomer of high-purity pumiloside was prepared and four metabolites in rats were identified.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2015
Type:
Article
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