Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

Shi-Fei LI; Shun-Lin LI

Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis / 中国天然药物

Shi-Fei LI; Shun-Lin LI.

Chinese Journal of Natural Medicines (English Ed.) ; (6): 950-954, 2017.

Article in En | WPRIM | ID: wpr-812036

Responsible library: WPRO

ABSTRACT

ABSTRACT

In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC value of 1.44 μmol·L and TI (Therapeutic Index) value of 15.59.

Subject(s)

Humans; Anti-HIV Agents; Pharmacology; Cell Line, Tumor; Cell Survival; Glucosides; Chemistry; Pharmacology; Toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Chemistry; Pharmacology; Toxicity; Senna Plant; Chemistry; Triterpenes; Chemistry; Pharmacology; Toxicity

Key words

Cassia occidentalis; Cycloartane triterpenoid; Cycloccidentalic acid C; Cycloccidentaliside VI

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Full text: 1 Index: WPRIM Main subject: Pharmacology / Triterpenes / Plant Extracts / Magnetic Resonance Spectroscopy / Molecular Structure / Cell Survival / Chemistry / Anti-HIV Agents / Inhibitory Concentration 50 / Senna Plant Limits: Humans Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article

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