A pair of cyclopeptide epimers from the seeds of Celosia argentea / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 63-69, 2018.
Article
in En
| WPRIM
| ID: wpr-812428
Responsible library:
WPRO
ABSTRACT
Two cyclopeptides, celogentin L (1) and its epimer lyciumin A (2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1D-, 2D-NMR, and HR-ESI/MS. The absolute configurations of amino acid components were assigned via chiral-phase HPLC analyses after acid hydrolysis. Furthermore, the configuration of C-N linkage at the glycine Cα was elucidated by extensive analyses of 2D-NMR and comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Cytotoxicity of the two compounds against human alveolar epithelial A549, hepatocellular carcinoma HepG2, and cervical cancer Hela cell lines was assayed. Although both of them were inactive in these cells, the present findings add new facets for the chemistry of Celosia argentea.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Peptides, Cyclic
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Seeds
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Stereoisomerism
/
HeLa Cells
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Molecular Structure
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Cell Survival
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Chemistry
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Chemistry Techniques, Analytical
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Celosia
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Toxicity
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Type:
Article