Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular protection, based on molecular docking / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 815-822, 2015.
Article
in En
| WPRIM
| ID: wpr-812476
Responsible library:
WPRO
ABSTRACT
As a computer-assisted approach, molecular docking has been universally applied in drug research and development and plays an important role in the investigation and evaluation of herbal medicines. Herein, the method was used to estimate the pharmacodynamics of Mai-Luo-Ning injection, a traditional Chinese compound herbal prescription. Through investigating the interactions between several important proteins in cardiovascular system and characteristic components of the formula, its effect on cardiovascular protection was evaluated. Results showed the differences in the interactions between each component and the selected target proteins and revealed the possible mechanisms for synergistic effects of various characteristic components on cardiovascular protection. The study provided scientific evidence supporting the mechanistic study of the interactions among multi-components and targets, offering a general approach to investigating the pharmacodynamics of complicated materials in compound herbal prescriptions.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Cardiovascular Agents
/
Cardiovascular System
/
Drug Synergism
/
Enzymes
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Molecular Docking Simulation
/
Metabolism
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2015
Type:
Article