Anti-asthmatic effects of oxymatrine in a mouse model of allergic asthma through regulating CD40 signaling / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 368-374, 2015.
Article
in English
| WPRIM
| ID: wpr-812533
ABSTRACT
The aim of the study was to investigate the anti-asthmatic effects of oxymatrine (OXY) and the possible underlying mechanisms. The mouse asthma model was established by ovalbumin (OVA) intraperitoneal injection. A total of fifty mice were randomly assigned to five groups control, OVA, OVA + dexamethasone (Dex, 2 mg · kg(-1)), and OVA + OXY (40 mg · kg(-1)), and OVA + OXY (80 mg · kg(-1)), respectively. Histological studies were conducted by the hematoxylin and eosin (HE) staining, the levels of interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13, and IgE were evaluated by enzyme-linked immunosorbent assay (ELISA), and the protein level of CD40 was analyzed by Western blotting. OXY inhibited OVA-induced increases in eosinophil count; the levels of IL-4, IL-5, IgE, and IL-13 were recovered. It also substantially inhibited OVA-induced eosinophilia in lung tissues and the expression of CD40 protein. These findings suggest that OXY may effectively ameliorate the progression of asthma and could be explored as a possible therapy for patients with allergic asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pulmonary Eosinophilia
/
Quinolizines
/
Asthma
/
Immunoglobulin E
/
Dexamethasone
/
Enzyme-Linked Immunosorbent Assay
/
Bronchoalveolar Lavage Fluid
/
Signal Transduction
/
Random Allocation
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2015
Type:
Article
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