Novel 9, 10-dihydrophenanthrene derivatives from Eria bambusifolia with cytotoxicity aganist human cancer cells in vitro / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 621-625, 2016.
Article
in En
| WPRIM
| ID: wpr-812584
Responsible library:
WPRO
ABSTRACT
The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1-10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L(-1)). These results provided a basis for future development of these agents as anticancer lead compounds.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Phenanthrenes
/
Plant Extracts
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
HL-60 Cells
/
Dendrobium
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article