Transformation of strictosamide to vincoside lactam by acid catalysis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 188-192, 2013.
Article
in En
| WPRIM
| ID: wpr-812673
Responsible library:
WPRO
ABSTRACT
AIM@#To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism.@*METHODS@#The acid-catalyzed reaction process of strictosamide was monitored by HPLC, and a macroporous resin was used to purify the reaction solution. The structure of the product was confirmed by MS, NMR, and ROESY spectra.@*RESULTS@#The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%.@*CONCLUSION@#The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound. These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis.
Full text:
1
Index:
WPRIM
Main subject:
Acids
/
Vinca Alkaloids
/
Molecular Structure
/
Catalysis
/
Chemistry
/
Lactams
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article