Synthesis of A B C-ring subunit of C-nor-D-homo-steroidal alkaloids: towards the total synthesis of cyclopamine / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 277-283, 2013.
Article
in En
| WPRIM
| ID: wpr-812692
Responsible library:
WPRO
ABSTRACT
A practical approach to the synthesis of the A, B and C-ring subunit of cyclopamine has been developed. This synthetic tactic highlights the utility of mandelate acetal-mediated resolution of the fused ring ketone (±)-4 and IBX-mediated oxidation cascades from 12 to 9. The availability of advanced intermediates from enantiomerically pure (+)-4 and 2 could provide efficient access to biologically active and structurally diverse C-nor-D-homo-steroidal alkaloids such as cyclopamine.
Full text:
1
Index:
WPRIM
Main subject:
Stereoisomerism
/
Steroids
/
Veratrum Alkaloids
/
Molecular Structure
/
Chemistry
/
Organic Chemistry Phenomena
/
Chemistry Techniques, Synthetic
/
Methods
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article