Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis / 中华男科学杂志
National Journal of Andrology
; (12): 1121-1126, 2017.
Article
in Zh
| WPRIM
| ID: wpr-812822
Responsible library:
WPRO
ABSTRACT
Objective@#To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility.@*METHODS@#We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software.@*RESULTS@#A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI 1.03-1.54, P = 0.023), 1.18 (95% CI 1.03-1.36, P = 0.018), and 1.20 (95% CI 1.05-1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI 1.05-1.45, P = 0.009) and 1.20 (95% CI 1.04-1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI 1.03-1.82, P = 0.003) and 1.21 (95% CI 1.00-1.47, P = 0.048), respectively.@*CONCLUSIONS@#In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Case-Control Studies
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Risk Factors
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Follicle Stimulating Hormone, Human
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Genetics
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Homozygote
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Infertility, Male
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limits:
Humans
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Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2017
Type:
Article