Toxicological characteristics of Ochratoxin A and its impact on male reproduction / 中华男科学杂志
National Journal of Andrology
; (12): 757-762, 2017.
Article
in Zh
| WPRIM
| ID: wpr-812882
Responsible library:
WPRO
ABSTRACT
Ochratoxin A (OTA) is found not only nephrotoxic, teratogenic, neurotoxic, and immunotoxic, but also reprotoxic for human and animals. In the recent decade, more attention has been paid to the impact of OTA on human reproduction and the studies of its underlying mechanisms. Many studies show that OTA affects the function of the reproductive system by acting as an endocrine disrupter and, as a testicular toxin, decreases sperm quality and even induces testis cancer. This review summarizes the toxicological characteristics and toxicokinetic process of OTA as well as recent progress in the studies of various toxic effects of OTA and their underlying mechanisms, hoping to call the attention from more people to the toxicity of OTA to male reproductive health.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Reproduction
/
Spermatozoa
/
Testicular Neoplasms
/
Testis
/
Pharmacokinetics
/
Endocrine Disruptors
/
Toxicity
/
Fertility
/
Ochratoxins
Limits:
Animals
/
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2017
Type:
Article