Expressions of survivin and nm23 and the relationship among the expressions and the axillary lymph node metastasis in breast cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 312-334, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813374
ABSTRACT
OBJECTIVE@#To investigate the expressions of Survivin protein and nm23 protein and the relationship among the expressions and axillary lymph node metastasis in breast cancer.@*METHODS@#The expression of Survivin and nm23 in 80 cases of breast cancer tissues were detected by immunohistochemistry SP method, and their correlation with axillary lymph node metastasis and 5-year disease free survival (DFS) were analysed.@*RESULTS@#Survivin protein positive expression rate was 68.75% (55/80) in breast cancer tissues, which had positive correlation with the axillary lymph nodes metastasis but negative correlation with 5 years FS (P 0.05).@*CONCLUSION@#The anti-apoptosis effect of Survivin protein and the anti-metastasis effect of nm23 protein may be important in the occurrence and advancement of breast cancer, suggesting that it may be a new indicator of prognostic and judgement in breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Axilla
/
General Surgery
/
Breast Neoplasms
/
Biomarkers, Tumor
/
Retrospective Studies
/
Nucleoside-Diphosphate Kinase
/
Inhibitor of Apoptosis Proteins
/
NM23 Nucleoside Diphosphate Kinases
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article
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