Effect of cyclosporine and simulect mono and combination therapy on cardiac allo-transplantation in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 549-552, 2005.
Article
in Zh
| WPRIM
| ID: wpr-813508
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effect of cyclosporine and simulect mono or combination therapy on cardiac allo-transplantation in rats.@*METHODS@#Recipients with allografts were treated with different doses of cyclosporine and/or simulect after cardiac allo-transplantation. Graft survival time was observed; the histopathological examination of graft tissues was performed; and levels of serum IL-2 and IL-4 were determined.@*RESULTS@#Mono or combination therapy with cyclosporine and/or simulect increased the survival of cardiac allografts. With the prolongation of survival time of the grafts, the rejection of grafts was moderated. The serum IL-2 level increased in acute rejected grafts; the serum IL-4 level increased evidently in long survival grafts.@*CONCLUSION@#Cyclosporine and simulect have an effect in the prolongation of cardiac allograft survival in rats, and the combination therapy shows an evident synergistic effect.
Full text:
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Index:
WPRIM
Main subject:
Pharmacology
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Recombinant Fusion Proteins
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Heart Transplantation
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Cyclosporine
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Rats, Wistar
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Rats, Sprague-Dawley
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Combined Modality Therapy
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Therapeutic Uses
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Allergy and Immunology
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Basiliximab
Limits:
Animals
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article