Oxidative stress in nitroglycerin tolerance and treatment with 3,4,5,6-tetrahydroxyxanthone / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 650-654, 2006.
Article
in Zh
| WPRIM
| ID: wpr-813628
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To determine the relationship between the nitroglycerin tolerance and the stimulation of radical oxygen species (ROS) production, and the therapeutical effect of 3,4,5,6-tetrahydroxyxanthone.@*METHODS@#Vasodilator responses to nitroglycerin were examined in the isolated thoracic aorta. The contents of ROS,and cGMP were determined in the cultured human umbilical vein endothelial cells.@*RESULTS@#3,4,5,6-tetrahydroxyxanthone could significantly reduce the inhibition of relaxation by nitroglycerin. 3,4,5,6-tetrahydroxyxanthone could significantly inhibit the ROS increase and increase the cGMP level.@*CONCLUSION@#Nitroglycerin tolerance is associated with the stimulation of ROS production,and the reversal of nitroglycerin tolerance with 3,4,5,6-tetrahydroxyxanthone is related to the reduction of ROS.
Full text:
1
Index:
WPRIM
Main subject:
Aorta, Thoracic
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Pharmacology
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Umbilical Veins
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Endothelium, Vascular
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Cells, Cultured
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Nitroglycerin
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Reactive Oxygen Species
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Rats, Sprague-Dawley
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Oxidative Stress
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Cell Biology
Limits:
Animals
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Humans
/
Male
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article