Immune tolerance induced by combined heart-thymus transplantation with intrathymic inoculation of thymocytes in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 85-90, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813760
ABSTRACT
OBJECTIVE@#To explore the role of allo heart and thymus transplantation by intrathymic inoculation of thymocytes.@*METHODS@#Wistar recipients were given intrathymic injection of allo thymocytes (2 x 10(7)) 14 days before the heart and/or thymus transplantation. Graft survival, histopathology, levels and mRNA expressions of IL-2, IL-4 in serum and cardiac-grafts were investigated.@*RESULTS@#Heart transplantation and heart-thymus composite transplantation with the treatment of CysA for 7 or 14 days prolonged graft survival. Heart transplantation and heart-thymus composite transplantation with intrathymic thymocytes injection induced the long-term survival of allo-grafts transiently immunosuppressed with CysA; IL-4 maintained at high levels but IL-2 kept at low levels in grafts in long-term survivals.@*CONCLUSION@#Intrathymic inoculation of allo thymoctyes can induce immune tolerance for both cardiac transplantation and heart-thymus combined transplantation in rats. Thymus graft may play a role in the induction and maintenance of central tolerance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thymus Gland
/
Transplantation
/
Blood
/
Heart Transplantation
/
Interleukin-4
/
Interleukin-2
/
Rats, Wistar
/
Rats, Sprague-Dawley
/
Cell Transplantation
/
Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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