Nested case-control study on the influence factors of perinatal stage transmission of hepatitis B virus / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 451-454, 2007.
Article
in Zh
| WPRIM
| ID: wpr-813862
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To determine the influence factors of perinatal stage transmission of hepatitis B virus (HBV) and to provide scientific evidence for the prevention of perinatal stag transmission of HBV.@*METHODS@#A 11 matched nested case-control study was conducted, and 141 pair of pregnant women with HBsAg-positive and their newborns were enrolled. A questionnaire was performed and blood-related indicators were detected. The data were dealt with single factor analysis and conditional logistic regression analysis using SPSS 13.0 and SAS 8.1.@*RESULTS@#Single factor paired Chi-square test showed that education, first class family history, disfunction of liver, serum glutamic-pyruvic transaminase, systematic treatment, intrahepatic cholestasis of pregnancy (ICP), fetal distress, and vaccinating hepatitis B immune globulin (HBIG) were the risk factors of perinatal stage transmission of HBV. Conditional logistic regression analysis indicated that first class family history, vaccinating HBIG, systematic treatment, and ICP were the risk factors of perinatal stage transmission of HBV.@*CONCLUSION@#For women with HB-sAg-positive, active treatment, the standard vaccination of HBIG, and preventing and controlling the incidence of ICP may reduce the incidence of perinatal stage transmission of HBV.
Full text:
1
Index:
WPRIM
Main subject:
Pregnancy Complications, Infectious
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Virology
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Blood
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Immunoglobulins
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Case-Control Studies
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Logistic Models
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Hepatitis B virus
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Infectious Disease Transmission, Vertical
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Therapeutic Uses
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Drug Therapy
Type of study:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article