Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1120-1125, 2009.
Article
in Zh
| WPRIM
| ID: wpr-814185
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.@*METHODS@#A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).@*RESULTS@#The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P0.05).@*CONCLUSION@#PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
Full text:
1
Index:
WPRIM
Main subject:
Phenylethanolamine N-Methyltransferase
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Polymorphism, Genetic
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Molecular Sequence Data
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Base Sequence
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Case-Control Studies
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China
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Sex Factors
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Genetic Predisposition to Disease
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Genetics
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Hypertension
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2009
Type:
Article