Association between CD24 polymorphism and genetic susceptibility to breast cancer: a case-control study / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1122-1129, 2013.
Article
in Zh
| WPRIM
| ID: wpr-814805
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the association between CD24 polymorphism and genetic susceptibility to breast cancer in Chongqing women of Han nationality.@*METHODS@#In the case-control study, single nucleotide polymorphism of CD24 (rs3838646 and rs52812045) was genotyped by Sequenom MassArray®iPLEX GOLD System in 170 patients with breast cancer and 178 healthy controls. Data were analyzed via t test, Chi-square test, and logistic regression analysis.@*RESULTS@#The distribution of CD24 rs3838646 genotype and allelotype had no significant difference between the patients with breast cancer and healthy controls (χ2=3.54, P=0.17; χ2=2.29, P=0.13). Stratified by menstruation status, premenopausal individuals carrying CD24 rs3838646 Del allele significantly reduced the risk (OR=0.51, 95% CI 0.26-1.00, P=0.0485) of breast cancer compared with the individuals carrying CD24 CA/CA genotype. The distribution of CD24 rs52812045 genotypes and allelotypes had no significant difference between the patients with breast cancer and healthy controls (χ2=5.37, P=0.07; χ2=3.05, P=0.08). Compared with C/C homozygotes, CD24 rs52812045 T/T homozygotes had a significantly reduced risk (OR=0.47, 95% CI 0.23-0.95; P=0.04) for breast cancer.@*CONCLUSION@#CD24 polymorphism may be a marker for susceptibility to breast cancer in Han population in southwestern China. CD24 polymorphisms may be associated with a reduced risk of breast cancer in Chinese population. Further studies are needed to confirm these findings.
Full text:
1
Index:
WPRIM
Main subject:
Breast Neoplasms
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Case-Control Studies
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China
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Asian People
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CD24 Antigen
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Genetics
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Genotype
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Female
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Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2013
Type:
Article