Role of HIF-induced EMT in invasion and
metastasis of tumor / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 872-878, 2016.
Article
in Zh
| WPRIM
| ID: wpr-814948
Responsible library:
WPRO
ABSTRACT
Hypoxia plays a vital role in tumor metabolism, proliferation, apoptosis, invasion and metastasis via hypoxia-inducible factor (HIF). Epithelial to mesenchymal transition (EMT) is a crucial process to metastasis, which could be triggered by hypoxia. EMT could be regulated by HIF via multiple pathways including TGF-β, Notch, and Wnt/β-catenin. It has been shown that anti-HIF drugs combined with anti-EMT therapies could be a promising strategy for tumor therapy.
Full text:
1
Index:
WPRIM
Main subject:
Transforming Growth Factor beta
/
Beta Catenin
/
Basic Helix-Loop-Helix Transcription Factors
/
Epithelial-Mesenchymal Transition
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
/
Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2016
Type:
Article