Immune pathogenesis of IgA nephropathy and its drugable targets / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 96-101, 2014.
Article
in Zh
| WPRIM
| ID: wpr-815455
Responsible library:
WPRO
ABSTRACT
IgA nephropathy (IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide. The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli. Dysregulation of the immune system plays an important role in the pathogenesis of IgAN. Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Immunoglobulin A
/
B-Lymphocytes
/
T-Lymphocytes
/
Chemistry
/
Glomerular Mesangium
/
Glomerulonephritis, IGA
/
Antigen-Antibody Complex
Type of study:
Etiology_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2014
Type:
Article