Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome

ABSTRACT

OBJECTIVE@#To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.@*METHODS@#Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.@*RESULTS@#Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).@*CONCLUSIONS@#The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.