Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia
Asian Pacific Journal of Tropical Medicine
; (12): 483-487, 2014.
Article
in En
| WPRIM
| ID: wpr-820666
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.@*METHODS@#Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI.@*RESULTS@#According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI 0.89-1.20) (P>0.05).@*CONCLUSIONS@#XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Epidemiology
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Genetic Predisposition to Disease
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DNA-Binding Proteins
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Asia, Eastern
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Genetics
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Lung Neoplasms
Type of study:
Observational_studies
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Systematic_reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article