Application of nuclear medical imaging in the diagnosis of myocardial amyloidosis / 中华核医学与分子影像杂志

ABSTRACT

Amyloidosis is a disease caused by abnormal deposition of amyloid protein, and the main types of amyloidosis involving myocardium are light chain amyloidosis (AL) and transthyretin-related amy-loidosis (ATTR). Different types of myocardial amyloidosis have different prognosis and treatment methods. Therefore, early diagnosis and classification are particularly important. Nuclear medical imaging can diag-nose and classify myocardial amyloidosis noninvasively. Radiotracers for bone scintigraphy has high sensitivi-ty and specificity for the diagnosis of ATTR, and have certain value for prognosis. Sympathetic innervation imaging tracers can detect cardiac sympathetic innervation, which may show myocardial involvement of amy-loidosis earlier than bone scintigraphy. Amyloid protein specific imaging agent, which was first used in the diagnosis of amyloidosis in nervous system, has also yielded good results from preliminary studies in myocar-dial amyloidosis, and the diagnostic specificity in AL is slightly better than that in ATTR. This review intro-duces the application of nuclear medical imaging in myocardial amyloidosis.