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Application of Single Cell Sequencing in Diagnosis and Treatment of Malignant Hematological Diseases--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1059-1063, 2020.
Article in Zh | WPRIM | ID: wpr-827161
Responsible library: WPRO
ABSTRACT
Abstract  Single cell sequencing technology is different from traditional sequencing method, which is based on population cell average level. It has been widely used in many fields and made great progress in the application of malignant hematological diseases. In this review, the principle, methodology and application of single cell sequencing technology in malignant hematological diseases are summarized briefly, including the study of the pathogenesis in myelodysplastic syndrome, the mechanism of transformation into leukemia, accurate diagnosis and classification, differential diagnosis, evaluation of targeted drug therapeutic efficacy and exploration of biomarkers; specific diagnostic indicators for myeloproliferative diseases, progression of disease monitoring and epidemiological studies; moreover, the pathogenesis and drug resistance of acute myeloid leukemia (AML), which can provide reference for the diagnosis and research of malignant hematological diseases.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Myelodysplastic Syndromes / Leukemia, Myeloid, Acute / Sequence Analysis / Hematologic Diseases / Myeloproliferative Disorders Type of study: Diagnostic_studies Limits: Humans Language: Zh Journal: Journal of Experimental Hematology Year: 2020 Type: Article
Full text: 1 Index: WPRIM Main subject: Myelodysplastic Syndromes / Leukemia, Myeloid, Acute / Sequence Analysis / Hematologic Diseases / Myeloproliferative Disorders Type of study: Diagnostic_studies Limits: Humans Language: Zh Journal: Journal of Experimental Hematology Year: 2020 Type: Article