Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1001-1005, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827171
ABSTRACT
OBJECTIVE@#To investigate whether collagen peptides can improve the immune functions of mice under the condition of simulated weightlessness.@*METHODS@#Mouse tail-suspension model was used to simulate the effects of weightlessness. Tail-suspended mice were intraperitoneally injected with 600 mg collagen peptides per kilogram body weight once a day for 10 days. Then, the mice were killed, and white blood cells were counted and classified. Lymphocyte subsets and T lymphocyte proliferations in spleens were analyzed.@*RESULTS@#Compared with normal control group, total and differential count of leukocytes, lymphocytes, T cells,CD4 and CD8 T cells, B cells and NK cells, and splenic T lymphocyte proliferation all decreased in the weightlessness simulated mice (P<0.05). Except for NK cells, the above-mentioned parameters were increased after administration of collagen peptides, and some of the parameters were recovered to the levels of normal control mice (P<0.05).@*CONCLUSION@#Collagen peptides can effectively improve peripheral blood lymphocyte distributions and T lymphocyte proliferations of mice under the condition of simulated weightlessness. This study nay provid the experimental basis for improvement of immune functions of astronauts.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Spleen
/
Weightlessness
/
Collagen
/
Weightlessness Simulation
/
Lymphocyte Count
/
CD8-Positive T-Lymphocytes
/
Cell Proliferation
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS