Prognostic value of plasma miR-1290 expression in patients with oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 371-375, 2020.
Article
in Zh
| WPRIM
| ID: wpr-827529
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the prognostic value of plasma miR-1290 in patients with oral squamous cell carcinoma (OSCC).@*METHODS@#Seventy patients with OSCC admitted to Danzhou People's Hospital from January 2014 to December 2018 were included in this study. Real-time fluorescence quantitative polymerase chain reaction (PCR) was used to detect the expression of miR-1290 in these patients. The optimal cut-off value of plasma miR-1290 expression was determined by the ROC curve method, and patients with OSCC were divided into the high (n=31) and low (n=39) miR-1290-expressing groups. The clinicopathological features of the two groups were compared, and survival curves were drawn using the Kaplan-Meier method. Risk factors affecting the poor prognosis of patients were analyzed using univariate and multivariate COX regression models.@*RESULTS@#The expression level of plasma miR-1290 in the OSCC group was significantly lower than that in the control group (0.65±0.14 vs. 2.06±0.90; t=13.912, P<0.001). The low expression of plasma miR-1290 appeared to be related to the clinical stage, differentiation degree, tumor diameter, and lymph node metastasis of OSCC (P<0.05). Survival analysis showed that the overall survival rate and the progression-free survival rate of the low-miR-1290 group were significantly lower than that of the high-miR-1290 group (P<0.01). Multivariate COX regression analysis showed that clinical stage, lymph node metastasis, and plasma miR-1290<1.14 were independent risk factors for the poor prognosis of patients with OSCC (P<0.05).@*CONCLUSIONS@#The expression level of plasma miR-1290 in patients with OSCC significantly decreased, and the low expression of miR-1290 is related to the short survival time of OSCC patients. Thus, miR-1290 may be a potential marker predicting the poor prognosis of OSCC.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
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Mouth Neoplasms
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Carcinoma, Squamous Cell
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Biomarkers, Tumor
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MicroRNAs
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Lymphatic Metastasis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
West China Journal of Stomatology
Year:
2020
Type:
Article