Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 729-737, 2020.
Article
in En
| WPRIM
| ID: wpr-827782
Responsible library:
WPRO
ABSTRACT
A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC74.0 ± 1.3 μmol·L) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.
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WPRIM
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2020
Type:
Article