Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 113-117, 2020.
Article
in Zh
| WPRIM
| ID: wpr-828533
Responsible library:
WPRO
ABSTRACT
Atherosclerosis is an important pathological basis for coronary artery disease. ANRIL is an antisense non-coding RNA located in Chr9p21 locus, which was identified as the most significant risk locus associated with atherosclerosis. ANRIL can produce multiple transcripts including linear and circular transcripts after various transcript splicing. It has been illustrated that ANRIL plays important roles in the pathology of atherosclerosis by regulating the proliferation and apoptosis of vascular cells. Linear ANRIL can regulate the proliferation of vascular smooth muscle cells (VSMCs) in plaques by chromatin modification, as well as influence the proliferation and the apoptosis of macrophages in post transcription; circular ANRIL can affect the proliferation and apoptosis of VSMCs by chromatin modification as well as interfering with rRNA maturation. In this review, we describe the ANRIL evolution, different transcripts characteristics, and their roles in the proliferation and apoptosis of vascular cells to participate in the process of atherosclerosis, for further understanding the pathogenesis of atherosclerosis and finding potential targets for diagnosis and treatment of atherosclerosis.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Apoptosis
/
Myocytes, Smooth Muscle
/
Cell Proliferation
/
Atherosclerosis
/
RNA, Long Noncoding
/
Genetics
/
Metabolism
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2020
Type:
Article