Poly adenosine diphosphate-ribosylation and neurodegenerative diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 100-106, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-828537
ABSTRACT
The morbidity of neurodegenerative diseases are increased in recent years, however, the treatment is limited. Poly ADP-ribosylation (PARylation) is a post-translational modification of protein that catalyzed by poly(ADP-ribose) polymerase (PARP). Studies have shown that PARylation is involved in many neurodegenerative diseases such as stroke, Parkinson's diseases, Alzheimer's disease, amyotrophic lateral sclerosis and so on, by affecting intracellular translocation of protein molecules, protein aggregation, protein activity, and cell death. PARP inhibitors have showed neuroprotective efficacy for neurodegenerative diseases in pre-clinical studies and phase Ⅰ clinical trials. To find new PARP inhibitors with more specific effects and specific pharmacokinetic characteristics will be the new direction for the treatment of neurodegenerative diseases. This paper reviews the recent progress on PARylation in neurodegenerative diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Poly Adenosine Diphosphate Ribose
/
Poly(ADP-ribose) Polymerases
/
Neurodegenerative Diseases
/
ADP-Ribosylation
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2020
Type:
Article
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