Drug resistance of direct-acting antivirals in genotype 2/3 hepatitis C virus / 临床肝胆病杂志
Journal of Clinical Hepatology
; (12): 2553-2556, 2020.
Article
in Zh
| WPRIM
| ID: wpr-829641
Responsible library:
WPRO
ABSTRACT
Since the development of direct-acting antivirals (DAAs) for hepatitis C virus(HCV), more than 95% of the patients with hepatitis C can be cured, but a very small proportion of patients still face treatment failure. There are many reasons for treatment failure, among which HCV genotype and resistance-associated substitutions (RASs) in virus genes show a certain impact. This article mainly introduces the RASs associated with the NS5B and NS5A gene fragments in genotype 2/3 HCV, summarizes the distribution of RASs, and compares the difference in the distribution of RASs between previously untreated chronic hepatitis C patients and patients with treatment failure.
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WPRIM
Language:
Zh
Journal:
Journal of Clinical Hepatology
Year:
2020
Type:
Article